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Spectinomycin (Trobicin)

Category:

  • Antibiotic

Description:

  • Miscellaneous antibiotic

Indications:

  • Gonorrhea due N. gonorrhoeae

Contraindications:

  • None

Precautions:

  • Pregnancy category B

  • Not effective against syphilis

  • Use spectinomycin only in patients intolerant to cephalosporins or quinolones

Adverse Reactions (Side Effects):

  • Single dose reactions: 

    • sore injection site

    • urticaria

    • dizziness

    • nausea

    • chills

    • fever

    • insomnia

  • Multiple-dose reactions: 

    • decreased hemoglobin, hematocrit and creatinine clearance

    • elevations of alkaline phosphatase, BUN and ALT  

 

 

Dosage:

  • Administered orally IM injection ONLY deep in upper outer quadrant of gluteal muscle

  • Uncomplicated gonococcal infections: 

    • 2 grams IM

  • Gonococcal infections in pregnancy: 

    • single 2 gram IM dose

  • Disseminated gonococcal infections: 

    • 2 grams q12h

  • Geographic areas having antibiotic resistance: 

    • 4 grams IM total (2 grams per each side)

 

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
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