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Temazepam (Restoril)

Category:

  • Hypnotic

Description:

  • Benzodiazepine hypnotic (DEA Schedule IV)

Indications:

  • Insomnia

Precautions:

  • Pregnancy category X; may cause sedation and poor feeding in nursing infant

  • Anemia, hepatic/renal disease, suicidal individuals

  • Drug abuse, elderly, depression, psychosis, children <18 years

  • Acute narrow-angle glaucoma, seizure disorders, lung disease

Adverse Reactions (Side Effects):

  • CNS: anxiety, confusion, daytime sedation, dizziness, drowsiness, headache, irritability, lethargy, lightheadedness, rebound insomnia

  • CV: chest pain, hypotension, tachycardia

  • GI: abdominal pain, anorexia, constipation, diarrhea, heartburn, nausea, vomiting

  • HEME: granulocytopenia (rare), leukopenia

  • RESP: respiratory depression, sleep apnea

 

 

Dosage:

Administered orally

  • Adult:   PO 15-30mg at bedtime; 7.5mg at bedtime may be sufficient for elderly or debilitated patients

Drug interactions:

  • Cimetidine, disulfiram: increased benzodiazepine levels

  • Clozapine: possible increased risk of cardiorespiratory collapse

  • Ethanol: adverse psychomotor effects

  • Rifampin: reduced benzodiazepine levels

 

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
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