Category:
Description:
-
Pyrimethamine
and sulfadoxine are used together in an oral preparation to treat or
prevent malaria, however, the combination is no longer recommended for
malaria prophylaxis due to the possibility of fatal toxic epidermal
necrolysis. Pyrimethamine
inhibits parasitic dihydrofolate reductase, and sulfadoxine
antagonizes parasitic para-aminobenzoic acid, thus causing the
bacteriostatic activity. The
ingredients are used together because of their synergistic activity on
folic acid production.
Indications:
|
Dosage:
Administered
orally: available as tablets:
-
pyrimethamine
25mg
-
sulfadoxine
500mg
Acute malaria, taken PO as a single dose. Also for acute, chloroquine-resistant malarial attack, take as a
single PO dose in combination with quinine
-
Adult
and child >45 kg: 3 tablets
-
Child
31-45 kg: 2 tablets
-
Child
21-30 kg: 1½ tablets
-
Child
11-20 kg: 1 tablet
-
Child
5-10 kg: ½ tablet
|
The information contained here is an abbreviated summary. For more detailed
and complete information, consult the manufacturer's product information sheets
or standard textbooks.
Source:
Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department
of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300
OB-GYN 101:
Introductory Obstetrics & Gynecology
© 2003, 2004, 2005, 2008
Brookside Associates, LLC
All rights reserved
|
