OB-GYN 101
Pharmacy

Category:

• Gastrointestinal

Description:

• Antiulcer agent

Indications:

• Gastroesophageal reflux disease (GERD)

• Gastric ulcer, duodenal ulcer (active and for suppression)

• Heartburn, acid indigestion, sour stomach due to over indulgence

Precautions:

• Pregnancy category B; excreted in breast milk (0.1% of dose)

• Renal insufficiency

Adverse Reactions (Side Effects):

• CNS: dizziness, drowsiness, headache

• CV: bradycardia, palpitation, tachycardia

• EENT: rhinitis

• GI: constipation, diarrhea, flatulence, hepatitis, nausea

• HEME: anemia, thrombocytopenia

• METAB: gynecomastia, hyperuricemia

• MS: myalgia

• SKIN: acne, pruritus, sweating, urticaria

Administered orally

• Adult:            

  • Heartburn, acid indigestion, sour stomach due to overindulgence: PO 75mg 2 times daily (OTC)

  • Active duodenal or benign gastric ulcer: PO 300mg at bedtime or 150mg 2 times daily for 4-8 weeks

  • Maintenance of healed duodenal ulcer: PO 150mg at bedtime

  • Gastroesophageal reflux disease: PO 15omg 2 times daily

Dosage adjustment of renal insufficiency (active ulcer disease), CrCl 20-50 mg/mil, 150mg once daily; CrCl <20 ml/min 150mg every other day