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Lymphogranuloma Venereum

lymphogranuloma venereum

lymphogranuloma venereum

Lymphogranuloma venereum is an uncommon sexually-transmitted disease caused by a variant of Chlamydia trachomatis.

Following initial exposure, there is mild, blister-like formation which is frequently unnoticed. Within the following month, there is ulceration of the vaginal, rectal or inguinal areas. At this stage, the disease is very painful, particularly with walking, sitting and with bowel movements. The stool may be blood-streaked.

Hard tender masses (buboes) arise in the inguinal area at this stage and are characteristic of the disease.

As the disease progresses untreated, extensive scarring in the rectal area may require surgery to enable normal bowel movements. Scarring in the vaginal area can lead to painful intercourse or make intercourse basically impossible.

Confirmation of the disease is optimally achieved with a positive Chlamydia trachomatis serotype culture from a bubo. Often, less specific tests, such as serum complement fixation test with acute and convalescent samples are used. In many operational settings, none of these tests are available and the diagnosis is made by history of exposure, visual appearance of the lesions and known prevalence in the population.

Optimal treatment is:

Because Azithromycin is effective against other presentations of Chlamydia trachomatis, it is likely, but unproven that use of multiple doses over several weeks would be effective against LGV (Azithromycin 1.0 g orally once weekly for 3 weeks)


CDC Treatment Guidelines

 


This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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