Doxycycline (Vibramycin) |
Category:
Description:
Indications:
-
Rickettsiae
infections (Rocky Mtn spotted fever, typhus fever, Q fever,
rickettsialpox and tick fevers)
-
Mycoplasma pneumoniae infections
-
Psittacosis
and ornithosis
-
Lymphogranuloma
venereum and granuloma inguinale
-
Borrelia recurrentis infections
-
Gram-negative
infections (E. coli,
Enterobacter aerogenes, Shigella species, Acinetobacter
calcoaceticus, H. influenzae, Klebsiella species,H.
ducreyi, Yersinia pestis, Francisella tularensis, Bartonella
bacilliformis, Bacteroides species, Campylobacter fetus, V. cholerae, Brucella species)
-
Gram-positive
infections (Streptococcus species, S. pyogenes, S. faecalis)
-
For
infections were penicillin is the drug-of-choice but is
contraindicated (N. gonorrhoeae, Treponema pallidum, T. pertenue, Listeria monocytogenes,
Clostridium species, Bacillus anthracis, Fusobacterium fusiforme, Actinomyces species, N.
meningitidis)
-
Acute
intestinal amebiasis
-
Uncomplicated
gonococcal infections (N.
gonorrhoeae, C. trachomatis, Ureaplasma urealyticum)
-
Lyme
disease (Borrelia burgdorferi)
-
Traveler’s
diarrhea (E.coli)
-
Rape
victim prophylaxis
Contraindications:
Precautions:
-
Pregnancy
category D
-
Do
not use in last half of pregnancy up to 8 years old due to tooth
discoloration
-
May
cause photosensitivity reactions
-
Prolonged
intraveneous (IV) administration may lead to thrombophlebitis,
initiate oral therapy as soon as possible
-
Doses
greater than 2 grams per day may lead to hepatic function impairment
Excreted
in breast milk
-
May
cause pseudotumor cerebri (benign intracranial hypertension with
symptoms of headache and blurred vision)
-
Do
not use after expiration date. Degraded,
expired tetracyclines are highly nephrotoxic.
-
May
be taken with food or milk.
-
Take
with a full glass of water and remain standing for at least 90 seconds
and/or lay down for 60 minutes to decrease occurrence of esophageal
ulcers.
-
Complete
full course of therapy.
Adverse
Reactions (Side Effects):
-
Anorexia,
nausea, vomiting, diarrhea, epigastric distress, loose stools, sore
throat
-
Esophageal
ulcers
-
Fatty
liver, hepatotoxicity, increased BUN levels
-
Urticaria
-
Local
injection site pain
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Dosage:
Administered
orally (capsules and suspension) and by IV injection
-
Adults
(Children >8 years old or >45kg):
-
Children
(>8 years old and <45kg):
-
Acute
gonorrhea:
-
Primary
and Secondary syphilis:
-
Traveler’s
diarrhea prophylaxis:
-
Endometriosis,
salpingitis, parametritis, peritonitis:
-
Chlamydia trachomatis:
-
Rape
victim prophylaxis:
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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