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Metronidazole (Flagyl, MetroGel, MetroGel Vaginal)

Category:

  • Antibiotic

Description:

  • Antiprotozoal

Indications:

Contraindications:

Trichomoniasis infections in the first trimester of pregnancy

Precautions:

  • Pregnancy category B

  • Use with caution in patients with organic CNS disease or severe hepatic dysfunction

  • Use condoms during therapy to avoid re-infection with trichomoniasis

  • Counsel patient to finish all medication

  • Avoid using alcohol during therapy and 1-2 days post-therapy to avoid “disulfiram-type” reaction

  • Will cause a metallic taste in the mouth

  • Take with food to avoid GI side effects

  • Will darken the color of urine  

Adverse Reactions (Side Effects):

  • Seizures and peripheral neuropathy

  • Gastrointestinal: anorexia, nausea, diarrhea, cramping, metallic taste

  • Headache

  • Rash

  • Dysuria and darkened urine

 

Dosage:

  • Administered orally, topically and IV injection

  • Acute intestinal amebiasis:

    • 750mg tid for 5-10 days

  • Amebic liver abscess amebiasis:

    • Adult: 500-750mg tid for 5-10 days

    • Children: 35-50mg/kg/day in three divided doses for 10 days

  • Trichomoniasis (treat sexual partner(s) also):

    • One day therapy: 2 grams in one or two doses

    • Seven day therapy: 250mg tid for 7 days

  • Anaerobic bacterial infections:

    • Initial: 15mg/kg infused over one hour

    • Maintenance: Six hours post loading dose, 75mg/kg (max 4 grams per day) oral or IV (infused over 1 hour) q6h for 7-10 days

  • Colorectal surgery prophylaxis:

    • 15mg/kg infused IV (over 1 hour) and completed one hour prior to surgery, then 7.5mg/kg at 6 and 12 hour intervals after initial dose.

  • Acne rosacea :

    • Apply a thin film twice a day for 3-9 weeks

  • Bacterial vaginosis :

    • Insert 1 applicatorful (5 grams or 37.5mg metronidazole) once or twice a day for 5 days

    • For once daily dosing, dose at bedtime

 

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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