BACTERIAL AGENTS

Bacteria are unicellular organisms. They vary in shape and size from spherical cells - cocci - with a diameter of 0.5-1.0 m m (micrometer), to long rod-shaped organisms - bacilli - which may be from 1-5 m m in size. Chains of bacilli may exceed 50 m m. The shape of the bacterial cell is determined by the rigid cell wall. The interior of the cell contains the nuclear material (DNA), cytoplasm, and cell membrane, that are necessary for the life of the bacterium. Many bacteria also have glycoproteins on their outer surfaces which aid in bacterial attachment to surface receptors on cells and are of special importance in their ability to cause disease. Under special circumstances some types of bacteria can transform into spores. The spore of the bacterial cell is more resistant to cold, heat, drying, chemicals and radiation than the bacterium itself. Spores are a dormant form of the bacterium and, like the seeds of plants, they can germinate when conditions are favorable.

Bacteria can cause diseases in human beings and animals by means of two mechanisms which differ in principle: in one case by invading the tissues, in the other by producing poisons (toxins). In many cases pathogenic bacteria possess both properties. The diseases they produce often respond to specific therapy with antibiotics. This manual will cover several of the bacteria or rickettsia considered to be potential BW threat agents: Bacillus anthracis (Anthrax), Brucella spp. (Brucellosis), Vibrio cholerae (Cholera), Burkholderia mallei (Glanders), Yersinia pestis (Plague), Francisella tularensis (Tularemia), and Coxiella burnetii (Q Fever).