Prochlorperazine (Compazine)

Category:

  • Miscellaneous

Description:

  • Antiemetic, antipsychotic

Indications:

  • Severe nausea and vomiting

  • Psychotic disorders

Contraindications:

  • Severe toxic CNS depression, coma, subcortical brain damage, bone marrow depression

  • Severe liver or cardiac disease, narrow-angle glaucoma, pediatric surgery

Precautions:

  • Pregnancy category C; evidence indicates safety in low doses; expect sedation in nursing infants

  • Children <5 years, prolonged use, cardiovascular disease, epilepsy

  • Hepatic or renal disease, glaucoma, prostatic hypertrophy, severe asthma

  • Emphysema, hypocalcemia, thyrotoxicosis, tartrazine sensitivity

Adverse Reactions (Side Effects):

  • CNS: agitation, anxiety, catatonic-like behavioral states, confusion, depression, drowsiness, EPS, euphoria, exacerbation of psychotic symptoms including hallucinations, headache, heat or cold intolerance, insomnia, lethargy, neuroleptic malignant syndrome, restlessness, seizures, vertigo

  • CV: ECG changes, hypertension, hypotension, tachycardia

  • EENT: blurred vision, cataracts, dry eyes, dry mouth, glaucoma, pigmentaion of retina or cornea, retinopathy

  • GI: anorexia, constipation, diarrhea, dyspepsia, hypersalivation, nausea, vomiting

  • GU: priapism, urinary retention

  • HEME: agranulocytosis, anemia, aplastic anemia, hemolytic anemia, leukocytosis, transient leukopenia

  • METAB: breast engorgement, gynecomastia, hyperglycemia, hyperprolactinemia, hypoglycemia, hyponatremia, impotence, increased libido, lactation, mastalgia, menstrual irregularities

  • RESP: bronchospasm, increased depth of respiration, laryngospasm

  • SKIN: diaphoresis, loss of hair, maculopapular and acneiform skin reactions, photosensitivity

Dosage:

Administered orally, intramuscularly, intravenously, rectally

  • Adult:            

    • Antiemetic: PO 5-10mg 3-4 times daily, usual max 40mg daily; PO extended release 10mg 2 times daily or 15mg once daily; IM 5-10mg every 3-4 hours, usual max 40mg daily; IV 2.5-10mg every 3-4 hours, max 10mg per dose, 40 mg/day; PR 25mg 2 times daily

    • Psychosis: PO 5-10mg 3-4 times daily, increase dose as needed, max 150mg daily; IM 10-20mg every 4 hours as needed, convert to PO as soon as possible

  • Child:            

    • Antiemetic: PO/PR 9-14kg: 2.5mg every 12 –24 hours, max 7.5mg daily; 14-18kg: 2.5mg every 8 hours or 5mg every 12 hours, max 15mg daily; IM 0.1-0.5 mg/kg/dose, convert to PO as soon as possible

    • Psychosis: PO/PR 2-12 years: 2.5mg 2-3 times daily, increase dose as needed, max 20mg daily; 2-5 years: 25mg daily; IM 6-12 years: 0.13 mg/kg/dose, convert to PO as soon as possible

 

Drug interactions:

·        Levodopa: inhibited effect of levodopa on Parkinson’s disease

·        Indomethacin: possible increased CNS side effects, other NSAIDs less likely to have effect

·        Narcotic analgesics: excessive CNS depression, hypotension, respiratory depression

 

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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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