Category:

• Analgesic

Description:

• Nonsteroidal anti-inflammatory drug (NSAID) analgesic

Indications:

• Inflammatory disease (rheumatoid and osteoarthritis)

• Mild to moderate pain (orthopedic pain, dental procedures, dysmenorrhea)

• Fever

Contraindications:

• Patients with aspirin or NSAID-induced nasal polyps, bronchospasm or angioedema

Precautions:

• Pregnancy Category C

• Patients may experience potentially serious GI effects, including GI bleeding and ulceration with prolonged, high dose therapy.

• Avoid use with anticoagulants (warfarin) due to increased bleeding times and potential for GI bleeding and decreased platelet aggregation.

Adverse Reactions (Side Effects):

• GI effects (nausea, heartburn, dyspepsia, pain)

• CNS effects (dizziness, headache, nervousness)

• Tinnitis, blurry vision  

Dosage:

Administered orally with food or milk to decrease GI effects

Inflammatory diseases:

• Adult:  400-800mg q6-8h (not to exceed 3.2 grams per day)

Pain:

• Adult: 200-400mg q4-6h as needed

• Children: 20-40mg/kg/day in divided doses q6-8h

Fever:

• Adult: 200-400mg q4-6h as needed

• Children: 5-10mg/kg q6-8h (maximum of 40mg per day)