Doxycycline (Vibramycin)
Category:
Description:
Indications:
-
Rickettsiae
infections (Rocky Mtn spotted fever, typhus fever, Q fever,
rickettsialpox and tick fevers)
-
Mycoplasma pneumoniae infections
-
Psittacosis
and ornithosis
-
Lymphogranuloma
venereum and granuloma inguinale
-
Borrelia recurrentis infections
-
Gram-negative
infections (E. coli,
Enterobacter aerogenes, Shigella species, Acinetobacter
calcoaceticus, H. influenzae, Klebsiella species,H.
ducreyi, Yersinia pestis, Francisella tularensis, Bartonella
bacilliformis, Bacteroides species, Campylobacter fetus, V. cholerae, Brucella species)
-
Gram-positive
infections (Streptococcus species, S. pyogenes, S. faecalis)
-
For
infections were penicillin is the drug-of-choice but is
contraindicated (N. gonorrhoeae, Treponema pallidum, T. pertenue, Listeria monocytogenes,
Clostridium species, Bacillus anthracis, Fusobacterium fusiforme, Actinomyces species, N.
meningitidis)
-
Acute
intestinal amebiasis
-
Uncomplicated
gonococcal infections (N.
gonorrhoeae, C. trachomatis, Ureaplasma urealyticum)
-
Lyme
disease (Borrelia burgdorferi)
-
Traveler’s
diarrhea (E.coli)
-
Rape
victim prophylaxis
Contraindications:
Precautions:
-
Pregnancy
category D
-
Do
not use in last half of pregnancy up to 8 years old due to tooth
discoloration
-
May
cause photosensitivity reactions
-
Prolonged
intraveneous (IV) administration may lead to thrombophlebitis,
initiate oral therapy as soon as possible
-
Doses
greater than 2 grams per day may lead to hepatic function impairment
Excreted
in breast milk
-
May
cause pseudotumor cerebri (benign intracranial hypertension with
symptoms of headache and blurred vision)
-
Do
not use after expiration date. Degraded,
expired tetracyclines are highly nephrotoxic.
-
May
be taken with food or milk.
-
Take
with a full glass of water and remain standing for at least 90 seconds
and/or lay down for 60 minutes to decrease occurrence of esophageal
ulcers.
-
Complete
full course of therapy.
Adverse
Reactions (Side Effects):
-
Anorexia,
nausea, vomiting, diarrhea, epigastric distress, loose stools, sore
throat
-
Esophageal
ulcers
-
Fatty
liver, hepatotoxicity, increased BUN levels
-
Urticaria
-
Local
injection site pain
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Dosage:
Administered
orally (capsules and suspension) and by IV injection
-
Adults
(Children >8 years old or >45kg):
-
Children
(>8 years old and <45kg):
-
Acute
gonorrhea:
-
Primary
and Secondary syphilis:
-
Traveler’s
diarrhea prophylaxis:
-
Endometriosis,
salpingitis, parametritis, peritonitis:
-
Chlamydia trachomatis:
-
Rape
victim prophylaxis:
|
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Distribution is unlimited. The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.
Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.
Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300 |
Operational Medicine
Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
January 1, 2001 |
United States Special Operations
Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323 |
*This web version is provided by The Brookside Associates, LLC. It contains
original contents from the official US Navy NAVMED P-5139, but has been
reformatted for web access and includes advertising and links that were not
present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the
Department of the Navy or the Department of Defense. The presence of any
advertising on these pages does not constitute an endorsement of that product or
service by either the US Department of Defense or the Brookside Associates. The
Brookside Associates is a private organization, not affiliated with the United
States Department of Defense.
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