Category:

• Antibiotic

Description:

• Cephalosporin, Third Generation

Indications:

• Uncomplicated urinary tract infections (E. coli and P. mirabilis)

• Otitis media (H. influenzae, Moraxella catarrhalis, S. pyogenes)

• Pharyngitis and tonsillitis (S. pyogenes)

• Acute bronchitis (S. pneumoniae, H. influenzae)

• Uncomplicated gonorrhea (N. gonorrhoeae)

Contraindications:

• Cross sensitivity with penicillin allergies

Precautions:

• Pregnancy category B

• Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

• Dosage modifications are generally only required in patients with severe renal impairment

• Counsel patient to finish all medication to prevent development of resistance

Adverse Reactions (Side Effects):

• Hypersensitivity reactions

• Gastrointestinal: nausea, vomiting, diarrhea

• Vaginitis

Dosage:

• Administered orally (tablets and suspension)

• Adults and Children (> 5o kg or > 12 years):

  • 400mg per day as a single dose or 200mg every 12 hours

• Children

  • 8mg/kg/day as a single dose or 4mg/kg/day every 12 hours

  • For oral suspension: room temperature, shake well, good for 10 days only