Vitamin B12 (Cyanocobalamin)
Category:
Description:
Indications:
Contraindications:
Precautions:
-
Pregnancy
category C
-
Vitamin
B12 deficiency is related to malabsorption syndrome seen in
patients with:
-
Pernious
anemia
-
GI
pathology, dysfunction or surgery,
-
Tapeworm
infestation
-
Pancreatic
or bowel malignancies
-
Sprue
-
Small
bowel bacterial overgrowth
-
Gastrectomy
-
Folic
acid deficiency.
-
If
the patient exhibits an inadequate response, it may be due to:
-
Patients
with Leber’s disease (hereditary optic nerve atrophy) suffer severe
and swift optic nerve atrophy.
-
Long-term
vitamin B12 deficiency may produce permanent degenerative
lesions on the spinal cord.
-
Give
a test dose of parenteral vitamin B12 due to cases of
anaphylactic reactions.
-
Vitamin
B12 deficiency is common in immunocompromised patients,
monitor AIDS and HIV patients vitamin B12 levels.
-
The
maximum amount of vitamin B12 absorbed per dose is 1-5mcg
and the percentages decreases with subsequent doses.
Adverse
Reactions (Side Effects):
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Dosage:
-
Dietary
sources: meat products (produced by microorganisms in animal
proteins), dairy products
-
Administered
in oral tablets, intranasal gel and injectable
-
Dietary
supplementation (RDA: recommended daily allowance):
-
Normal
dosing:
-
oral:
up to 1000mcg per day
-
parenteral:
IM or SQ: 30mcg per day for 3-10 days, then followed by 100-200mcg
on a monthly basis
-
Addisonian
pernious anemia:
-
IV
therapy is required for life
-
100mcg
per day for 6-7 days by deep IM or SQ injection
-
if
improvement occurs, give every other day for 2 weeks, then every
3-4 days for another 2-3 weeks, then 100mcg per day for remainder
of life
|
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Distribution is unlimited. The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.
Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.
Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300 |
Operational Medicine
Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
January 1, 2001 |
United States Special Operations
Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323 |
*This web version is provided by The Brookside Associates, LLC. It contains
original contents from the official US Navy NAVMED P-5139, but has been
reformatted for web access and includes advertising and links that were not
present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the
Department of the Navy or the Department of Defense. The presence of any
advertising on these pages does not constitute an endorsement of that product or
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