Category:

• Antibiotic

Description:

• Penicillin

Indications:

• Mild to moderate infections, primarily gram-negative (i.e.; genitourinary, susceptible anaerobic bacterial infections of the respiratory tract, intra-abdominal abscess, endometriosis, skin/soft tissue infections)

• susceptible strains of P. aeruginosa, Proteus species, E. coli, Enterobacter species, Streptococcus faecelis

Contraindications:

• None

Precautions:

• Pregnancy category B

• Use with caution in patients with PCN or cephalosporin allergy (5-10% chance of cross-reactivity)

• Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

• Hypersensitivity

• Gastrointestinal: nausea, diarrhea

• Vaginitis

Dosage:

Administered by IV injection

• Bacterial septicemia, resp tract infections, skin/soft tissue infections, intra-abdominal infections, female pelvic and genital tract infections:

  • Adult and Child:

  • 200-300mg/kg/day in divided doses every 4-6 hours

• Urinary Tract Infections (complicated)

  • Adult and Child:

  • 150-200mg/kg/day in divided doses every 4-6 hours

• Urinary Tract Infections (uncomplicated)

  • Adult:

    • 1 gram Im or direct IV every 6 hours

  • Child (< 40kg)

    • 50-100mg/kg/day IM or direct IV in divided doses every 6 hours

  • Neonatal infections

    • give IM or in 10-20 minute IV infusions

    • dose based on age and weight