Sulfisoxazole
Category:
Description:
Indications:
-
Chancroid
-
Inclusion
conjunctivitis
-
Malaria
(adjunctive therapy)
-
Meningitis
(H. influenzae and
meninogococcal)
-
Nocardiosis
-
Acute
otitis media (caused by H.
influenzae when used with penicillins)
-
Toxoplasmosis
-
Trachoma
-
Urinary
tract infections (pyelonephritis, cystitis)
-
Lymphogranuloma venereum (alternative to doxycycline)
-
Chlamydia trachomatic infections (alternative to doxycycline and
azithromycin)
Contraindications:
-
Hypersensitivity
to sulfa-related medications (sulfonylureas, thiazide and loop
diuretics, carbonic anhydrase inhibitors, sunscreens with PABA, local
anesthetics)
-
Pregnancy
at term
-
Lactation
-
Infants
less than 2 months old (except congenital toxoplasmosis as adjunct
with pyrimethamine)
Precautions:
-
Pregnancy
category C
-
Sulfonamides
have been associated with severe hypersensitivity reactions and death.
-
Serious
blood disorders (agranulocytosis, hepatocellular necrosis, aplastic
anemia) have been associated with sulfonamides. Perform complete blood counts. Symptoms of sore throat, fever, pallor, purpura or jaundice may
be early signs of serious blood disorders.
-
Use
with caution in patients with severe asthma or allergies.
-
Hemolytic
anemia may occur in patients with G-6-PD deficiency.
-
Photosensitization
may occur, caution patients to use protective measures against
ultraviolet or sunlight until tolerance is determined.
-
Sulfonamides
increase the effect of oral anticoagulants (warfarin).
-
Take
with a full glass of water and increase fluid intake to 2-3 liters per
day.
-
Complete
full course of therapy.
Adverse
Reactions (Side Effects):
-
Headache,
peripheral neuropathy, depression
-
Tinnitis,
vertigo
-
Nausea,
emesis, abdominal pain, anorexia, diarrhea
-
Hepatitis,
pancreatitis, stomatitis
-
Urticaria,
Stevens-Johnson type erythema multiforme
-
Crystalluria,
elevated creatinine
-
Drug
fever, chills
-
Photosensitivity
|
Dosage:
Administered
orally (tablets)
-
Adults:
-
Children
(>2 months):
|
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Distribution is unlimited. The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.
Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.
Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300 |
Operational Medicine
Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
January 1, 2001 |
United States Special Operations
Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323 |
*This web version is provided by The Brookside Associates, LLC. It contains
original contents from the official US Navy NAVMED P-5139, but has been
reformatted for web access and includes advertising and links that were not
present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the
Department of the Navy or the Department of Defense. The presence of any
advertising on these pages does not constitute an endorsement of that product or
service by either the US Department of Defense or the Brookside Associates. The
Brookside Associates is a private organization, not affiliated with the United
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