Category:

• Antibiotic

Description:

• Topical anti-infective

Indications:

• Topical ointment

  • impetigo caused by  S. aureus, S. pyogenes, beta-hemolytic streptococcus

• Topical cream

  • treatment of secondarily infected traumatic skin lesions due to S. aureus, S. pyogenes

• Nasal

  • eradication of methicillin-resistant S. aureus

Contraindications:

• None

Precautions:

• Pregnancy category B

• For external use only, avoid contact with eyes

• Polyethylene glycol can be absorbed through open wounds

Adverse Reactions (Side Effects):

• Topical ointment

  • burning

  • stinging

  • itching

  • rash

  • nausea

  • dry skin

  • erythema

• Topical cream

  • headache

  • rash

  • nausea

  • abdominal pain

• Nasal

  • Headache (9%)

  • rhinitis (6%)

  • upper respiratory congestion

  • pharyngitis

  • taste changes

Dosage:

• Administered topically, may be covered with gauze dressing

• Topical ointment

  • Apply a small amount to surface 3 times per day, re-evaluate in 3-5 days

• Topical cream

  • Apply a small amount to surface 3 times per day for 10 days

• Nasal

  • Apply small amount to nostril interior twice a day (morning and evening) for 5 days

  • After application, pinch nostrils together and release repeatedly for ~1 minute