Category:

• Antibiotic

Description:

• Penicillinase-Resistant Penicillin

Indications:

• Mild to moderate infections caused by penicillinase-producing staphylococci

• Upper Respiratory Tract Infections

• Localized soft tissue/skin infections

• Lower Respiratory Tract Infections

• Disseminated infections

Contraindications:

• None

Precautions:

• Pregnancy category B

• Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)

• Counsel patient to finish all medication to prevent development of resistance

• Inform patient to take at even intervals, preferably around the clock

• Take on an empty stomach, 1 hour before or 2 hours after meals.  Food inhibits absorption

Adverse Reactions (Side Effects):

• Hypersensitivity

• Gastrointestinal: nausea, vomiting, diarrhea

• Vaginitis  

Dosage:

• Administered orally (capsules and pediatric suspension)

• Adult and children (>20kg):

  • 250-500mg q6h

• Child (<20kg):

  • 50-100mg/kg in divided doses q6h

  • oral suspension:  refrigerate, shake well, good for 14 days