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Estradiol

Estradiol (Estrogen) is a female hormone, produced primarily in the ovary. The amount of estrogen produced depends on the phase of the menstrual cycle.

Men also produce estradiol, but only very small amounts.

Shortly before ovulation, estradiol levels surge and then fall immediately after ovulation. They then rise again and remain elevated until 2-3 days before menstruation.

  • If pregnancy occurs, the estradiol levels remain elevated. 
  • If pregnancy does not occur, then estradiol levels fall, which, in combination with falling progesterone levels, provoke a menstrual flow.

Elevations found in:

  • Pregnancy
  • Ovulation
  • Second half of the menstrual cycle
  • Congenital adrenal hyperplasia
  • Some hormone-producing tumors of the ovary
  • Polycystic Ovary Syndrome (PCO, Stein-Levinthal Syndrome)
  • Amenorrhea-Galactorrhea Syndrome
  • Liver disease

Decreases found in:

  • Menopause
  • Pituitary failure
  • Adrenal failure
  • Ovarian failure
  • Luteal Phase Deficiency

Normal Values*

Men 13-42 pg/ml

Women 
     (Proliferative Phase)

60-250 pg/ml
Women
     (Luteal Phase)
75-450 pg/ml
Women 
     (Menopausal)
<10 pg/ml
Women
     (Menopausal on 
       estrogen replacement)
50-100 pg/ml

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.


 

 

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Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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