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CK (Creatinine Kinase)
CPK (Creatinine Phosphokinase)
CK/CPK Isoenzymes

Creatinine Kinase (CK, CPK) is an enzyme found primarily in the heart and skeletal muscles, and to a lesser extent in the brain. Significant injury to any of these structures will lead to a measurable increase in CK levels.

Elevations found in:

  • Myocardial infarction
  • Crushing muscular trauma
  • Any cardiac or muscle disease, but not myesthenia gravis or multiple sclerosis
  • Brain injury
  • Hypothyroidism
  • Hypokalemia
  • Once elevated, CK remains elevated for several days, if the injury is acute. 
  • If there is on-going injury, the CK will remain elevated indefinitely.

Note:

  • In acute MI, CK usually rises faster than SGOT and returns to normal faster than the SGOT.

CK/CPK Isoenzymes

There are three Isoenzymes. Measuring them is of value in the presence of elevated levels of CK or CKP to determine the source of the elevation.

Isoenzyme MM BB MB
Synonym CK3 CK1 CK2
Found in: Skeletal M.
Heart M.
Brain
GI Tract
GU Tract
Heart M.
  • Normal levels of CK/CPK are almost entirely MM, from skeletal muscle.
  • Elevated levels of CK/CPK resulting from acute myocardial infarction are about half MM and half MB

Normal Values for CK, CPK*

Men 5-100 IU/L

Women

10-70 IU/L
Pregnancy 5-40 IU/L

Normal Values for CK or CPK Isoenzymes*

MM 97%-100% 

MB

0%-3% 
BB 0%

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.

 

 

 


 

 

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Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates Medical Education Division.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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Operational Medicine 2001
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