Category:

• Antibiotic

Description:

• Penicillin with beta-lactamase inhibitor

• 100mg potassium clavunate per 3 grams of ticarcillin

Indications:

• Mild to moderate infections (i.e.; septicemia, lower respiratory tract, urinary tract, skin , bone, joint, intra-abdominal, and gynecological infections)

• susceptible strains of H. influenzae, P. aeruginosa, S. aureus, E. coli, Klebsiella species, S. epidermidis,Citrobacter species, Serratia marcescens, B. melaninogenicus  Enterobacter species

Contraindications:

• None

Precautions:

• Pregnancy category B

• Use with caution in patients with PCN or cephalosporin allergy (5-10% chance of cross-reactivity)

• Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

• Hypersensitivity

• Gastrointestinal: nausea, diarrhea

• Vaginitis  

Dosage:

Administered by IV injection over 30 minutes

• Adult (> 60kg):

  • 3.1 grams every 4-6 hours

• moderate gynecological infections: 

  • 200mg/kg/day every 6 hours

• severe gynecological infections: 

  • 300mg/kg/day every 4 hours

  • Adult (< 60kg): 200-300mg/kg/day every 4-6 hours

  • Child (> 60kg):mild to moderate infections: 3.1 grams every 6 hours

• severe infections: 3.1 grams every 4 hours

  • Child (< 60kg):

  • dosed at 50mg/kg/dose

• mild to moderate infections: 200mg/kg/day every 6 hours

• severe infections: 300mg/kg/day every 4 hours