Prochlorperazine
(Compazine)
Category:
Description:
Indications:
Contraindications:
-
Severe
toxic CNS depression, coma, subcortical brain damage, bone marrow
depression
-
Severe
liver or cardiac disease, narrow-angle glaucoma, pediatric surgery
Precautions:
-
Pregnancy
category C; evidence indicates safety in low doses; expect sedation in
nursing infants
-
Children
<5 years, prolonged use, cardiovascular disease, epilepsy
-
Hepatic
or renal disease, glaucoma, prostatic hypertrophy, severe asthma
-
Emphysema,
hypocalcemia, thyrotoxicosis, tartrazine sensitivity
Adverse
Reactions (Side Effects):
-
CNS:
agitation, anxiety, catatonic-like behavioral states, confusion,
depression, drowsiness, EPS, euphoria, exacerbation of psychotic
symptoms including hallucinations, headache, heat or cold intolerance,
insomnia, lethargy, neuroleptic malignant syndrome, restlessness,
seizures, vertigo
-
CV:
ECG changes, hypertension, hypotension, tachycardia
-
EENT:
blurred vision, cataracts, dry eyes, dry mouth, glaucoma, pigmentaion
of retina or cornea, retinopathy
-
GI:
anorexia, constipation, diarrhea, dyspepsia, hypersalivation, nausea,
vomiting
-
GU:
priapism, urinary retention
-
HEME:
agranulocytosis, anemia, aplastic anemia, hemolytic anemia,
leukocytosis, transient leukopenia
-
METAB:
breast engorgement, gynecomastia, hyperglycemia, hyperprolactinemia,
hypoglycemia, hyponatremia, impotence, increased libido, lactation,
mastalgia, menstrual irregularities
-
RESP:
bronchospasm, increased depth of respiration, laryngospasm
-
SKIN:
diaphoresis, loss of hair, maculopapular and acneiform skin reactions,
photosensitivity
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Dosage:
Administered
orally, intramuscularly, intravenously, rectally
-
Adult:
-
Antiemetic: PO 5-10mg 3-4 times daily, usual max 40mg daily; PO extended
release 10mg 2 times daily or 15mg once daily; IM 5-10mg every 3-4
hours, usual max 40mg daily; IV 2.5-10mg every 3-4 hours, max 10mg
per dose, 40 mg/day; PR 25mg 2 times daily
-
Psychosis: PO 5-10mg 3-4 times daily, increase dose as needed, max 150mg
daily; IM 10-20mg every 4 hours as needed, convert to PO as soon
as possible
-
Child:
-
Antiemetic: PO/PR 9-14kg: 2.5mg every 12 –24 hours, max 7.5mg daily;
14-18kg: 2.5mg every 8 hours or 5mg every 12 hours, max 15mg
daily; IM 0.1-0.5 mg/kg/dose, convert to PO as soon as possible
-
Psychosis: PO/PR 2-12 years: 2.5mg 2-3 times daily, increase dose as
needed, max 20mg daily; 2-5 years: 25mg daily; IM 6-12 years: 0.13
mg/kg/dose, convert to PO as soon as possible
Drug
interactions:
· Levodopa:
inhibited effect of levodopa on Parkinson’s disease
· Indomethacin:
possible increased CNS side effects, other NSAIDs less likely to have
effect
· Narcotic
analgesics: excessive CNS depression, hypotension, respiratory depression
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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