Penicillin
G Aqueous (Pfizerpen)
Category:
Description:
Indications:
-
Meningococcal
menigitis/septicemia
-
Actinomycosis
-
Clostridial
infections (botulism, gas gangrene and tetanus)
-
Fusopirochetal
infections
-
Rat-bite
fever
-
Listeria
infections
-
Pasteurella
infections
-
Erysipeloid
endocarditis
-
Diphtheria
(adjunct to antitoxin to prevent carrier state)
-
Anthrax
-
Serious
streptococcal infections
-
Syphilis
(neurosyphilis)
-
Disseminated
gonococcal infections
-
Lyme
disease (non-FDA approved indication)
Contraindications:
Precautions:
-
Pregnancy
category B
-
Use
with caution in patients with penicillin or cephalosporin allergy
(5-10% chance of cross-reactivity)
-
Counsel
patient to finish all medication to prevent development of resistance
-
Intramuscular
injection or continuous IV infusion are preferred routes of
administration
-
Dosage
modifications are generally only required in patients with severe
renal impairment
Adverse
Reactions (Side Effects):
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Dosage:
Administered
by injection (available in powder for injection and premixed/frozen)
-
Meningococcal
menigitis/septicemia:
-
Adult:
24 million units per day (1-2 million units q2h)
-
Adult:
200,000-300,000 units/kg/day q2-4h in divided doses for 24 doses
total
-
Children:
250,000 units/kg/day divided equally q4h for 7-14 days
-
Actinomycosis:
-
Clostridial
infections
-
Fusopirochetal
infections
-
Rat-bite
fever
-
Adult:
12-20 million units/day q4-6h for 3-4 weeks
-
Children:
150,000-250,000 units/kg/day divided equally q4h for 4 weeks
-
Listeria
infections
-
Pasteurella
infections
-
Erysipeloid
endocarditis
-
Diphtheria
-
Adult:
2-3 million units/day q4-6h for 10-12 days
-
Children:
150,000-250,000 units/kg/day divided equally q6h for 7-10 days
-
Anthrax
-
Serious
streptococcal infections
-
Syphilis
-
Disseminated
gonococcal infections
-
Lyme
disease
-
use
oral penicllin V for erythema chronicum migrans
-
200,000-300,000
units/kg/day IV for 10-14 days
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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