Category:

• Analgesic

Description:

• Nonsteroidal anti-inflammatory drug (NSAID) analgesic

Indications:

• Inflammatory disease (rheumatoid and osteoarthritis)

• Mild to moderate pain (orthopedic pain, dental procedures, dysmenorrhea)

• Gout  

Contraindications:

• Patients with aspirin or NSAID-induced nasal polyps, bronchospasm or angioedema  

Precautions:

• Patients may experience potentially serious GI effects, including GI bleeding and ulceration with prolonged, high dose therapy.

• Avoid use with anticoagulants (warfarin) due to increased bleeding times and potential for GI bleeding and decreased platelet aggregation.

• May mask signs of infection, use with caution in the presence of infection.

• Compliance with therapy is essential, may take up to two weeks to see noticeable improvement.

• Always take with food, after meal or with antacids to decrease GI upset.

• Pregnancy Category 

Adverse Reactions (Side Effects):

• GI effects (nausea, heartburn, dyspepsia, pain)

• CNS effects (drowsiness, dizziness, headache, nervousness)

• Tinnitis, blurry vision, headache

Dosage:

Administered orally with food or milk to decrease GI effects

Inflammatory diseases:

• Adult:  25-50mg, q8-12h (not to exceed 200mg per day)

Pain:

• Adult: 75-150mg daily in three to four divided doses until pain alleviated

Gout:

• Adult: 50mg tid until attack subsides