Estradiol
(Estrase, Estraderm) |
Category:
Description:
Indications:
-
Menopausal
vasomotor symptoms (hot flashes, etc.)
-
Female
hypogonadism
-
Female
castration and primary ovarian failure
-
Atrophic
conditions caused by deficient estrogen production
Contraindications:
-
Known
or suspected breast cancer
-
Known
or suspected estrogen-dependent neoplasia
-
Known
or suspected pregnancy
-
Undiagnosed
genital bleeding
-
Current
or history of thrombophlebitis, thrombosis, thromboembolic disorders
(except when used in breast or prostatic cancer treatment).
Precautions:
-
Pregnancy
category X
-
Use
with caution in patients with hypertension, diabetes, epilepsy,
cardiac, liver or renal dysfunction, history of depression, gall
bladder disease, hepatic adenoma.
-
Use
with caution in nursing mothers.
-
Use
with extreme caution in women with a family history of breast cancer
or who have breast nodules.
-
Perform
periodic breast examinations.
-
Rotate
patch application sites to decrease skin sensitivity.
-
May
decrease glucose intolerance in diabetic patients.
-
Discontinue
therapy and contact health care provider if pregnancy is suspected.
Adverse
Reactions (Side Effects):
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Dosage:
-
Administered
orally or transdermal patch
-
1-2gm
per day, attempting to achieve lowest possible dose
-
10-20cm2 per patch applied twice weekly, rotating sites (avoid breasts and
waistline)
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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