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Ceftriaxone (Rocephin)

Category:

  • Antibiotic

Description:

  • Cephalosporin, Third Generation

Indications:

  • Lower respiratory tract infections (S. pneumoniae, S. aureus, E. coli, Klebsiella pneumoniae, H. influenzae H. parainfluenzae, Serratia marcescens, E. aerogenes, P. mirabilis)

  • Urinary tract infections (E. coli, K. pneumoniae, P. vulgaris, Morganella morgani, P. miribalis)

  • Intra-abdominal infections (E. coli, K. pneumoniae, B. fragilis, Clostridium species, Peptostreptococcus species)

  • Skin, bone and joint infections (S. aureus, S. epidermidi S. pyogenes, viridans group streptococci, E. coli, Enterobacter cloacae, K. oxytoca, K. pneumoniae, P. miribalis, P. aeruginosa, Morganella morganii, S. marcescens, Actinetobacter calcoaceticus, B, fragilis, Peptostreptococcus species)

  • Uncomplicated gonorrhea (N. gonorrhoeae)

  • Pelvic inflammatory disease (N. gonorrhoeae)

  • Bacterial septicemia (S. pneumoniae, S. aureus, E. coli, K. pneumoniae, H. influenzae)

  • Meningitis (H. influenzae, N. meningitidis, S. pneumoniae)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered by injection (IM and IV)

  • Adults:

    • 1-2 grams once a day (or divided into two equal does) [maximum daily 4 grams]

  • uncomplicated gonococcal infections: 

    • 250mg single IM dose

  • surgical prophylaxis: 

    • 1 gram IV dose 30 to 120 minutes pre-surgery

  • Children:

    • 50-75mg/kg/day in two equally divided doses (maximum daily dose 2 grams)

  • meningitis: 

    • 100mg/kg/day given once daily or divided into two doses(maximum daily dose 4 grams)

  • Gonorrhea, chancroid, pelvic inflammatory disease:

  • uncomplicated: 

    • 125mg IM as single dose plus 1 gram azithromycin single dose or 100mg doxycycline bid for 7 days

  • conjunctivitis: 

    • 1 gram IM single dose

    • disseminated: 1 gram IM or IV every 24 hours

  • Meningitis:

    • 1-2 grams IV every 12 hours for 10-14 days

  • Endocarditis:

    • 1-2 grams IV every 12 hours for greater than 4 weeks

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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