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Ceftizoxime (Cefizox)

Category:

  • Antibiotic

Description:

  • Cephalosporin, Third Generation

Indications:

  • Lower respiratory tract infections (Streptococcus species, H. influenzae, Klebsiella species, S. aureus, E. coli, Serratia species, Enterobacter species, P. mirabilis, Bacteroides species)

  • Urinary tract infections (S. aureus, E. coli, Klebsiella species, P. mirabilis, P. vulgaris, Providencia rettgeri, Morganella morganii, Serratia species, Enterobacter species, Pseudomonas species)

  • Gonorrhea (N. gonorrhoeae)

  • Pelvic inflammatory disease (N. gonorrhoeae, E. coli, S. agalactiae)

  • Intra-abdominal infections (E. coli, S. epidermidis, Streptococcus species, Enterobacter species, Klebsiella species, Bacteroides species, Peptococcus and Peptostreptococcus species)

  • Septicemia (Streptococcus species, Klebsiella species, S. aureus, E. coli, Serratia species, Bacteroides species)

  • Skin, bone and joint infections (S. aureus, S. epidermidis, E. coli, Klebsiella species, Streptococcus species, P. mirabilis, Serratia species, Enterobacter species, Bacteroides species (including Peptococcus and Peptostreptococcus species))

  • Meningitis (H. influenzae)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered by injection (IM and IV)

  • Adults:

    • 1-2 grams IV or IM every 8-12 hours

  • uncomplicated urinary tract infections: 

    • 500mg IV or IM every 12 hours

  • PID: 

    • 2 grams IV every 8 hours

  • other sites 

    • 1 gram Ivor IM every 8-12 hours

  • severe or refractory infections: 

    • 1 gram IM or IV every 8 hours or 2 grams IM or IV every 8-12 hours

  • life-threatening infections: 

    • 3-4 grams IV every 8 hours

  • uncomplicated gonorrhea: 

    • 1 gram single IM injection

  • Child (> 6 months)

    • 50-200mg/kg/day IV every 6-8 hours (maximum 6 grams per day)

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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