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Cefoxitin (Mefoxin)

Category:

  • Antibiotic

Description:

  • Cephalosporin, Second Generation

Indications:

  • Lower respiratory tract infections (S. pneumoniae, other streptococcus species, S. aureus, E. coli, Klebsiella species, H. influenzae, Bacteriodes  species)

  • Urinary tract infections (E. coli, Klebsiella species, indole-positive Proteus species (including P. vulgaris, Morganella morgani ), P. miribalis, Providencia rettgeri, N. gonorrhoeae)

  • Gynecological infections (E. coli, N. gonorrhoeae, Bacteriodes  species, Clostridium species, Peptococcus and Peptostreptococcus species and group B streptococci)

  • Intra-abdominal infections (E. coli, Klebsiella species, Bacteriodes  species, Clostridium species)

  • Skin, bone and joint infections (S. aureus, S. epidermidis, streptococcus species, E. coli, P. miribalis, Klebsiella species, Bacteriodes  species, Clostridium species, Peptococcus and Peptostreptococcus species)

  • Septicemia (S. pneumoniae, S. aureus, E. coli, Klebsiella species, Bacteriodes  species)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  

Dosage:

  • Administered by IM or IV injection

  • Adults:

    • 1-2 grams every 6-8 hours IM or IV for 5-10 days

  • Child:

    • 80-160mg/kg/day in divided does every 4-6 hours

  • Uncomplicated infections:

    • 3-4 grams per day (1 gram q6-8h IV)

  • Moderate to severe infections:

    • 6-8 grams per day (1 gram q4h IV or 2 grams q6-8h IV)

  • Infections generally requiring high dosages (gas gangrene):

    • 12 grams per day (2 grams q4h IV or 3 grams q6h IV)

  • Uncomplicated gonorrhea: 

    • 2g IM with 1 gram oral probenecid given concurrently

  • Perioperative prophylaxis:

    • Pre-op: 2 grams IV, 30 to 60 minutes pre-surgery

    • Post-op: 2 grams q6h IV for less than 24 hours

  • Cesarean section prophylaxis:

    • 2 gram IN as soon as umbilical cord is clamped

    • if three dose regimen: 2d and 3rd doses of 2 grams IV given 4 & 8 hours after first dose

  • Transurethral prostatectomy prophylaxis:

    • 1 gram IV pre-op and 1 gram q8h IV for less than 5 days

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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