Aspirin
(Bayer, Ecotrin, St. Joseph, Norwich, Easprin, Zorprin) |
Category:
Description:
Indications:
-
Mild
to moderated pain/fever, inflammatory conditions such as rheumatoid
arthritis and osteoarthritis, rheumatic fever
-
Thromboembolic
disorders
-
Reducing
risk of transient ischemic attacks; reducing risk of death or nonfatal
MI in patients with previous MI or unstable angina
Contraindications:
-
Hypersensitivity
to salicylates, NSAIDs, or tartrazine (FDA yellow dye #5)
-
GI
bleeding, hemophilia, hemorrhagic states
Precautions:
-
Pregnancy
category C (D in full doses during 3rd trimester)
-
Anemia,
asthma, nasal polyps, nasal allergies, hepatic disease, renal disease
-
Pre/postoperatively,
children/teenagers with flu-like symptoms (may be associated with the
development of Reye’s syndrome)
-
Gout,
history of coagulation defects, bleeding disorders
Adverse
Reactions (Side Effects):
-
CNS:
confusion, dizziness, drowsiness, headache
-
EENT:
dimness of vision, reversible hearing loss, tinnitus
-
GI:
acute reversible hepatotoxicity, anorexia, cholestasis, dyspepsia,
epigastric discomfort, GI bleeding, heartburn, nausea, increased
aminase levels
-
HEME:
hyperuricemia (low dose), hyperuricemia (high dose), leukopenia,
prolonged bleeding time, shortened erythrocyte survival time,
thrombocytopenia
-
METAB:
hypoglycemia, hypokalemia, hyponatremia
-
RESP:
hyperpnea, wheezing
-
SKIN:
angioedema, bruising, hives, rash, urticaria
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Dosage:
Administered
orally and rectally
-
Adult:
-
Arthritis: PO 2.6-5.2 g/day in divided doses every 4-6 hours
-
Pain/fever: PO/PR 325-650mg every 4 hours as needed, not to exceed 4g daily
-
Transient
ischemic attacks:
-
MI
prophylaxis: PO 165-325mg daily
-
Child:
-
Arthritis: PO 60-90 mg/kg per day in divided doses; usually maintenance dose
80-100 mg/kg daily divided every 6-8 hours; maintain serum
salicylate level of 150-300 mcg/ml
-
Pain/fever: PO/PR 10-15 mg/kg per dose every 4-6 hours as needed
Drug
Interactions:
-
Methotrexate:
increased serum concentration and enhanced methotrexate toxicity
-
Oral
anticoagulants: increased risk of bleeding by inhibiting platelet
function and possibly by producing gastric erosions
-
Warfarin:
enhanced hypoprothrombinemic effect of warfarin
Note:
-
Not
to be given to children with flu-like symptoms, Reye’s syndrome may
develop
-
Therapeutic
response may take two weeks (arthritis)
-
Administer
with food
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Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
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agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
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