Vitamin
C (Ascorbic Acid) |
Category:
Description:
Indications:
-
Vitamin
C deficiency
-
necessary
for collagen and dentin formation and tissue repair
-
Scurvy
treatment and prophylaxis
-
Antioxidant
-
Urine
acidifier (at high doses >2 grams per day)
-
Idiopathic
methemoglobinemia (150mg per day)
Contraindications:
Precautions:
-
Pregnancy
category C
-
Excessive
vitamin C doses may should not be adminstered to patients with
diabetes, prone to renal calculi, undergoing stool occult blood tests,
sodium restrictive diets or on anticoagulants.
-
High
dose administration to pregnant women may cause the fetus to become
“sensitized” to the levels and may experience “withdrawa”
after delivery.
-
Some
products contain tartrazine and/or sulfite, use in caution in patients
who are sensitive to these agents.
-
Ascorbic
acid increases serum levels of estrogens, use caution in patients
receiving estrogen replacement therapy or oral contraceptives.
-
Ascorbic
acid may reduce the anticoagulant effect of warfarin.
-
Large
dose of vitamin C (>500mg) may cause false-positive urine glucose
determinations.
-
Do
not administer vitamin C within 48-72 hours of an stool occult blood
test due to false negatives.
Adverse
Reactions (Side Effects):
-
Relatively
non-toxic in therapeutic doses
-
Large
dose may cause diarrhea and precipitation of renal stones.
-
Transient
mild soreness may occur at IM or SQ injection site.
-
Too
rapid of IV administration may cause temporary faintness or dizziness.
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Dosage:
-
Dietary
sources: citric juices, fresh vegetables and fruit, potatoes
-
Administered
orally or IV
-
Dietary
supplementation (RDA: recommended daily allowance):
-
Scurvy:
100-300mg per day over several days will reverse scurvy effects
-
Infants:
-
Enhanced
wound healing: 300-500mg per day for 7-10 days pre- and
post-operatively
-
Burn
patients: 1-2 grams per day
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Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
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agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
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or the Brookside Associates. All material presented here is unclassified.
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