Propranolol
(Inderal, Inderal LA)
Category:
Description:
Indications:
-
Hypertension,
cardiac dysrhythmias, MI, hypertrophic subaortic stenosis
-
Adjunctive
therapy of pheochromocytoma, migraine prophylaxis, angina pectoris
-
Essential
tremor
Contraindications:
-
Cardiogenic
shock, 2nd or 3rd degree heart block, sinus
bradycardia, CHF unless secondary to a tachydysrhythmia treatable with
beta-blockers
-
Bronchial
asthma or bronchospasm, severe COPD, cardiac failure
Precautions:
-
Pregnancy
category C
-
Major
surgery, diabetes mellitus, renal disease, hepatic disease, thyroid
disease
-
Well
compensated heart failure, peripheral vascular disease, bradycardia
-
Down’s
syndrome
Adverse
Reactions (Side Effects):
-
CNS:
depression, dizziness, drowsiness, fatigue, lethargy, hallucinations
-
CV:
bradycardia, CHF, cold extremities, postural hypotension, 2nd or 3rd
degree heart block, profound hypotension
-
EENT:
dry burning eyes, sore throat, visual disturbances
-
GI:
diarrhea, dry mouth, elevated LFT’s, ischemic colitis, mesenteric
arterial thrombosis, nausea, vomiting
-
GU:
impotence, sexual dysfunction
-
HEME:
agranulocytosis, thrombocytopenia
-
RESP:
Bronchospasm, dyspnea, wheezing
-
SKIN:
alopecia, pruritis, rash
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Dosage:
Administered
orally, intravenously
-
Adult:
-
Child:
-
Dysrhythmias:
-
PO
0.5-1 mg/kg/day divided every 6-8 hours, increase dose at 3-7
day intervals, usual range 2-4 mg/kg/day, max 16 mg/kg/day or
60mg daily
-
IV
0.01-0.1 mg/kg slowly over 10 minutes, max 1mg
-
Hypertension:
-
Migraine
prophylaxis:
Special
Consideration:
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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