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Nizatidine (Axid)

Category:

  • Gastrointestinal

Description:

  • Antiulcer agent

Indications:

  • Gastroesophageal reflux disease (GERD)

  • Gastric ulcer, duodenal ulcer (active and for suppression)

  • Heartburn, acid indigestion, sour stomach due to over indulgence

Precautions:

  • Pregnancy category B; excreted in breast milk (0.1% of dose)

  • Renal insufficiency

Adverse Reactions (Side Effects):

  • CNS: dizziness, drowsiness, headache

  • CV: bradycardia, palpitation, tachycardia

  • EENT: rhinitis

  • GI: constipation, diarrhea, flatulence, hepatitis, nausea

  • HEME: anemia, thrombocytopenia

  • METAB: gynecomastia, hyperuricemia

  • MS: myalgia

  • SKIN: acne, pruritus, sweating, urticaria

Dosage:

Administered orally

  • Adult:            

    • Heartburn, acid indigestion, sour stomach due to overindulgence: PO 75mg 2 times daily (OTC)

    • Active duodenal or benign gastric ulcer: PO 300mg at bedtime or 150mg 2 times daily for 4-8 weeks

    • Maintenance of healed duodenal ulcer: PO 150mg at bedtime

    • Gastroesophageal reflux disease: PO 15omg 2 times daily

Dosage adjustment of renal insufficiency (active ulcer disease), CrCl 20-50 mg/mil, 150mg once daily; CrCl <20 ml/min 150mg every other day

           

 

 

 

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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