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Metaraminol (Aramine)

Category:

  • Nervous system

Description:

  • Vasopressor

Indications:

  • Acute hypotensive states associated with spinal anesthesia, hemorrhage, reactions to medications, surgical complications

  • Shock associated with brain damage resulting from trauma or tumor

  • “Probably effective” in hypotension due to cardiogenic shock or septicemia

Contraindications:

  • Use with cyclopropane or halothane anesthesia

Precautions:

  • Pregnancy category D

  • Prolonged administration, heart disease, thyroid disease, hypertension, diabetes

  • Cirrhosis, extravasation (phentolamine is antidote), history of malaria

  • Sulfite sensitivity

Adverse Reactions (Side Effects):

  • CNS: apprehension, dizziness, headache, tremors

  • CV: cardiac arrest, flushing, hypertension, hypotension (following cessation), palpitation, sinus tachycardia, ventricular tachycardia, other dysrhymias

  • GI: nausea

  • SKIN: extravasation (abscess, necrosis, sloughing), sweating

Dosage:

Administered subcutaneously, intramuscularly, intravenously

  • Adult:   

    • SC/IM 2-10mg

    • IV INF dilute 15-500mg in 500mg D5W or NS, administer at a rate adjusted to maintain desired blood pressure

    • IV 0.5-5mg as a single dose in severe shock, follow with IV INF

  • Child: 

    • SC/IM 0.1 mg/kg or 3 mg/meter square

    • IV INF 0.4 mg/kg or 12 mg/meter square, diluted and administered at a rate adjusted to maintain desired blood pressure

    • IV 0.01 mg/kg or 0.3 mg/meter square as a single dose in severe shock, follow with IV INF

 

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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