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Levofloxacin (Levaquin)

Category:

  • Antibiotic

Description:

  • Fluoroquinolone antibiotic

Indications:

  • Acute maxillary sinusitis (S. pneumoniae, H. influenzae, M. catarrhalis)

  • Acute bacterial exacerbation of chronic bronchitis (H. influenzae, H. parainfluenzae, M. catarrhalis, S. aureus, S. pneumoniae)

  • Community-acquired pnemonia (S. aureus, S. pneumoniae, H. influenzae, H. parainfluenzae, K. pneumoniae,M. catarrhalis, Chlamydia pneumoniae, Legionella pneumophila,Mycoplasma pneumoniae)

  • Skin infections (S. pyogenes, S. aureus)

  • Complicate urinary tract infections (Enterbacter cloacae, Enterococcus faecalis, E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa)

  • Uncomplicated urinary tract infections (E. coli, K. pneumoniae, S. saprophyticus)

  • Acute pyelonephritis (E. coli)

Contraindications:

  • None

Precautions:

  • Pregnancy category C

  • May cause photosensitivity reactions

  • May cause pseudomembranous colitis

  • Do not use in young children due to possible cartilage abnormalities

  • May cause ophthalmologic abnormalities

  • Administer on an empty stomach

  • Do not take with antacids, iron, aluminum, magnesium or zinc preparations, milk or dairy products, take 2 hours before or 2 hours after

  • May cause dizziness or lightheadedness, use caution when performing tasks

  • Take each dose with a full glass of water

  • Complete full course of therapy

  • Administer by IV infusion only over a period of not less than 60 minutes, DO NOT administer by IM, intrathecal, intraperitoneal or SQ

  • Dosage modifications are required in patients with renal impairment

Adverse Reactions (Side Effects):

  • Bad taste in mouth

  • Nausea, anorexia

  • Headache, dizziness, insomnia, restlessness

Dosage:

  • Administered orally (tablets) and by IV injection

  • Acute bacterial exacerbation of chronic bronchitis: 

    • 500mg po q24h for 7 days

  • Community-acquired pneumonia: 

    • 500mg po q24h for 7-14 days

  • Acute maxillary sinusitis: 

    • 500mg po q24h for 10-14 days

  • Uncomplicated skin infection: 

    • 500mg po q24h for 7-10 days

  • Complicated UTIs: 

    • 250mg po q24h for 10 days

  • Uncomplicated UTIs: 

    • 250mg po q24h for 3 days

  • Acute pyelonephritis: 

    • 250mg po q24h for 10 days

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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