Heparin
(Liquaemin) |
Category:
Description:
Indications:
-
Venous
thrombosis, pulmonary embolism, peripheral arterial embolism
-
Coagulopathies,
DVT/PE prophylaxis, clotting prevention in arterial and heart surgery
-
Blood
transfusions, extracorporeal circulation, dialysis and blood samples
Contraindications:
-
Severe
thrombocytopenia, uncontrolled bleeding (except when due to DIC)
-
Suspected
intracrainial hemorrhage, shock, severe hypotension
Precautions:
-
Pregnancy
category C; does not cross placental barrier; not excreted in breast
milk
-
IM
injection (avoid due to risk for hematoma)
-
Elderly,
children, diabetes, renal
insufficiency, severe hypertension
-
Subacute
bacterial endocarditis, acute nephritis, peptic ulcer disease, sever
renal disease
Adverse
Reactions (Side Effects):
-
CNS:
fever, rash
-
CV:
allergic vasospastic reactions, shock
-
EENT:
lacrimation, rhinitis
-
GI:
nausea, vomiting
-
GU:
hematuria, priapism
-
HEME:
hemorrhage, thrombocytopenia, white clot syndrome
-
RESP:
anaphylactoid reactions, asthma
-
SKIN:
chills, cutaneous necrosis, delayed transient alopecia, erythema,
histamine-like reactions, local irritation, urticaria
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Dosage:
Administered
SC and IV
-
Adult:
-
DVT/PE:
-
IV
INF 50-100 u/kg initially, then 15-25 u/kg/hr, adjusted based
on APTT
results; intermittent IV 10,000u initially, then 75-125 u/kg
every 4-6 hours
-
SC
10,000-20,000u initially, then 8,000-10,000u every 8 hours or
15,000-20,000u every 12 hours
-
Prevent
DVT/PE:
-
Child:
-
IV
INF 50 u/kg initially, then 15-25 u/kg/hr, increase dose by 2-4
u/kg/hr every 6-8 hours based on aPTT results
-
Intermittent
IV 50-100 u/kg initially, then 50-100 u/kg every 4 hours
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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