Flurbiprofen
(Ansaid, Ocufen) |
Category:
Description:
Indications:
-
Rheumatoid
arthritis, osteoarthritis, ankylosing spondylitis
-
Inhibition
of inoperative miosis (ophth), cystoid macular edema (non-FDA
approved)
-
Inflammation
after cataract or glaucoma laser surgery or uveitis syndromes (ophth:
non-FDA approved)
-
Bursitis,
primary dysmenorrhea, tendinitis, acute gout (all non-FDA approved)
Contraindications:
Precautions:
-
Pregnancy
category C; excreted in breast milk; use caution in nursing mothers
-
Bleeding
tendencies, peptic ulcer
-
Hepatic/renal
function impairment, elderly, CHF, hypertension
Adverse
Reactions (Side Effects):
-
CNS:
dizziness, headache, lightheadedness
-
CV:
chest pain, CHF, dysrhythmias, edema, hyper/hypotension, palpitation,
tachycardia
-
EENT:
burning or stinging upon instillation, dry eyes, hearing disturbances,
photophobia, tinnitus, visual disturbances
-
GI:
abdominal cramps, constipation, diarrhea, dyspepsia, flatulence,
gastric or duodenal ulcer with bleeding or perforation, hepatitis,
nausea, occult blood in stool, pancreatitis, vomiting
-
GU:
renal failure
-
HEME:
agranulocytosis, eosinophilia, leukopenia, pancytopenia,
thrombocytopenia
-
METAB:
hyperglycemia, hyperkalemia, hypoglycemia, hyponatremia,
-
RESP:
bronchospasm, dyspnea
-
SKIN:
photosensitivity, rash, urticaria
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Dosage:
Drug
interactions:
-
Warfarin:
addition of flurbiprofen associated with excessive hypoprothrombinemia
and bleeding; ibuprofen less likely to interact
-
Methotrexate:
addition of flurbiprofen may interfere with the renal secretion of
methotrexate, yielding increased risk of methotrexate toxicity
-
Prednisone:
increase risk of GI ulceration
-
Loop
diuretics: reduction in diuretic and antihypertensive effects
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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