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Estrogens and Methyltestosterone (Estratest, Estratest H.S.)

Category:

  • Hormonal

Description:

  • Estrogen and Androgen combination hormone replacement

  • Estratest: 1.25mg esterified estrogens, 2.5mg methyltestosterone

  • Estratest H.S.: 0.625mg esterified estrogens, 1.25mg methyltestosterone

Indications:

  • Menopausal vasomotor symptoms (hot flashes, etc.)

  • Postpartum breast engorgement

Contraindications:

  • Known or suspected breast cancer (except those being treated for metastatic disease)

  • Known or suspected estrogen-dependent neoplasia

  • Known or suspected pregnancy

  • Undiagnosed abnormal genital bleeding

  • Current or history of thrombophlebitis, thrombosis, thromboembolic disorders (except when used in breast or prostatic cancer treatment).

Precautions:

  • Pregnancy category X

  • Use with caution in nursing mothers and patients with hypertension, diabetes, asthma, epilepsy, migraine, cardiac or renal dysfunction, history of depression, pre-existing uterine leiomyotoma, history of jaundice during pregnancy, impaired liver function, metabolic bone disorders and in young women (and men).

  • Take with food to avoid GI side effects.

  • May decrease glucose intolerance in diabetic patients.

  • Discontinue therapy and contact health care provider if pregnancy is suspected.

  • Rule out breast cancer prior to initiating treatment.

  • May cause irreversible androgenic effects (hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy)

Adverse Reactions (Side Effects):

  • Rash, acne, alopecia, nausea

  • Abnormal menstrual bleeding, changes in cervical secretions

  • Edema, weight change

  • Depression, insomnia, somnolence

  • Androgenic: acne, oily kin/hair, weight gain, mild hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy, testicular hypotrophy

  • Hypoestrogenic: flushing, sweating, vaginitis, nervousness, emotional disorders

  • Hepatic dysfunction

  • CNS: dizziness, headache, sleep disorders, fatigue

  • Muscle cramps, joint pain and swelling

Dosage:

  • Administered orally

  • Menopausal vasomotor symptoms: 1 tablet per day

  • Postpartum breast engorgement: 1 tablet per day for 5 days

For more information on the use of conjugated estrogens and methyltestosterone, read:

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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