Estrogens
and Methyltestosterone (Estratest, Estratest H.S.) |
Category:
Description:
-
Estrogen
and Androgen combination hormone replacement
-
Estratest:
1.25mg esterified estrogens, 2.5mg methyltestosterone
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Estratest
H.S.: 0.625mg esterified estrogens, 1.25mg methyltestosterone
Indications:
Contraindications:
-
Known
or suspected breast cancer (except those being treated for metastatic
disease)
-
Known
or suspected estrogen-dependent neoplasia
-
Known
or suspected pregnancy
-
Undiagnosed
abnormal genital bleeding
-
Current
or history of thrombophlebitis, thrombosis, thromboembolic disorders
(except when used in breast or prostatic cancer treatment).
Precautions:
-
Pregnancy
category X
-
Use
with caution in nursing mothers and patients with hypertension,
diabetes, asthma, epilepsy, migraine, cardiac or renal dysfunction,
history of depression, pre-existing uterine leiomyotoma, history of
jaundice during pregnancy, impaired liver function, metabolic bone
disorders and in young women (and men).
-
Take
with food to avoid GI side effects.
-
May
decrease glucose intolerance in diabetic patients.
-
Discontinue
therapy and contact health care provider if pregnancy is suspected.
-
Rule
out breast cancer prior to initiating treatment.
-
May
cause irreversible androgenic effects (hirsutism, decreased breast
size, deepening of voice, clitoral hypertrophy)
Adverse
Reactions (Side Effects):
-
Rash,
acne, alopecia, nausea
-
Abnormal
menstrual bleeding, changes in cervical secretions
-
Edema,
weight change
-
Depression,
insomnia, somnolence
-
Androgenic:
acne, oily kin/hair, weight gain, mild hirsutism, decreased breast
size, deepening of voice, clitoral hypertrophy, testicular hypotrophy
-
Hypoestrogenic:
flushing, sweating, vaginitis, nervousness, emotional disorders
-
Hepatic
dysfunction
-
CNS:
dizziness, headache, sleep disorders, fatigue
-
Muscle
cramps, joint pain and swelling
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Dosage:
For more information on the use of conjugated estrogens and
methyltestosterone, read:
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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