Enalapril/Enalaprilat
(Vasotec) |
Category:
Description:
Indications:
Precautions:
-
Pregnancy
category C (1st trimester), category D (2nd and
3rd trimesters); ACE inhibitors can cause fetal and
neonatal morbidity and death when administered to pregnant women
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Impaired
renal function, dialysis patients, hypovolemia, diuretic therapy
-
Collagen-vascular
diseases, CHF, elderly, bilateral renal artery stenosis
Adverse
Reactions (Side Effects):
-
CNS:
anxiety, dizziness, fatigue, headache, insomnia, paresthesia
-
CV:
angina, hypotension, palpitations, postural hypotension, syncope
-
GI:
abdominal pain, constipation, melena, nausea, vomiting
-
GU:
decreased libido, impotence, increased BUN/creatinine, UTI
-
METAB:
hyperkalemia, hyponatremia
-
MS:
arthralgia, arthritis, myalgia
-
RESP:
asthma, bronchitis, cough, dyspnea, sinusitis
-
SKIN:
angioedema, flushing, rash, sweating
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Dosage:
Administered
orally, intravenously
-
Adult: PO 2.5-5mg daily, increase as needed, usually 10-40mg daily
divided 1-2 times; IV (enalaprilat) 0.625-1.25 mg/dose given over 5
minutes every 6 hours; dosing adjustment in renal impairment: CrCl
10-50 ml/min, 75%-100% of normal dose; CrCl <10 ml/min, 50% of
normal dose
-
Child: PO 0.1 mg/kg/day initially, increase as needed over 2 weeks to
max of 0.5 mg/kg/day; IV (enalaprilat) 5-10 mcg/kg/dose every 8-24
hours
Drug
interactions:
-
Allopurinal:
predisposition to hypersensitivity reactions to ACE inhibitors
-
Aspirin,
NSAIDS: inhibition of the antihypertensive response to Ace inhibitors
-
Prazosin,
terazosin, doxazosin: exaggerated first-dose hypotensive response to a-blockers
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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