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Ceftazidime (Fortaz, Ceptaz, Tazicef, Tazidime)

Category:

  • Antibiotic

Description:

  • Cephalosporin, Third Generation

Indications:

  • Lower respiratory tract infections (P. aeruginosa  and other Pseudomanas species, H. influenzae, Klebsiella species, S. pneumoniae, S. aureus, E. coli, Serratia species, Enterobacter species, P. mirabilis, Citrobacter species)

  • Urinary tract infections (E. coli, Klebsiella species, Proteus species, Enterobacter species, P. aeruginosa)

  • Skin, bone and joint infections (P. aeruginosa, Enterobacter species, E. coli, Proteus species, Klebsiella species, Serratia species, E. coli, S. aureus, S. pyogenes)

  • Intra-abdominal infections (E. coli, Klebsiella species, S. aureus, Bacteroides species, polymicrobial infections caused by aerobic and anaerobic organisms)

  • Bacterial septicemia (P. aeruginosa, Klebsiella species, H. influenzae, E. coli, Serratia species, S. pneumoniae, S. aureus)

  • Gynecological infections (E. coli)

  • CNS infections (H. influenzae, N. meningitidis)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered by injection (IM and IV)

  • Adults:

    • 1 gram IV or IM every 8-12 hours

  • uncomplicated urinary tract infections: 

    • 250mg IV or IM every 12 hours

  • complicated urinary tract infections: 

    • 500mg IV or IM every 8-12 hours

  • meningitis: 

    • 2 grams IV every 8 hours

  • uncomplicated pneumonia, mild skin infections: 

    • 500mg – 1 gram IV or IM every 8 hours

  • bone and joint infections: 

    • 2 grams IV every 12 hours

  • meningitis: 

    • 2 grams IV every 8 hours

  • severe, life-threatening infections: 

    • 2 grams IV every 8 hours

  • pseudomonal lung infections: 

    • 30-50mg/kg IV every 8 hours (maximum 6 grams per day)

  • Infants and Children (1 month – 1 year)

    • 30-50mg/kg IV every 8 hours (maximum 6 grams per day)

  • Neonates (0-4 weeks):

    • 30mg/kg IV every 12 hours

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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