Category:
Description:
Indications:
-
Hypertension,
heart failure, left ventricular dysfunction after MI
-
Diabetic
nephropathy in Type 1 patients (proteinuria > 500mg/daily)
Contraindications:
Precautions:
-
Pregnancy
category C (1st trimester) and D (3rd trimester)
-
Dialysis
patients, hypovolemia, leukemia, scleroderma, lupus erythematosus
-
Blood
dyscrasias, thyroid disease, COPD, asthma, CHF, hyperkalemia
-
Potassium
sparing diruretics, cough, aortic stenosis, pediatric use
Adverse
Reactions (Side Effects):
-
CNS:
chills, fever
-
CV:
chest pain, hypotension, palpitations, postural hypotension,
tachycardia
-
GI:
loss of taste
-
GU:
acute reversible renal failure, dysuria, frequency, impotence,
nephrotic syndrome, oliguria, polyuria, proteinuria
-
HEME:
agranulocytosis, neutropenia
-
METAB:
hyperkalemia, hyponatremia
-
RESP:
angioedema, bronchospasm, cough, dyspnea
-
SKIN:
rash
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Dosage:
Administered
orally
-
Adult:
-
Hypertensive
crisis: PO 25mg, increasing every 2 hours until desired
response; do not exceed 450mg daily
-
Hypertension: PO initial dose 12.5mg 2-3 times daily; may increase to 50mg 2-3
times daily at 1-2 week intervals; usual range 25-150mg 2-3 times
daily; max 450mg daily
-
Diabetic
nephropathy: PO 25mg 3 times daily
-
Congestive
heart failure: PO 12.5mg 2-3 times daily; may increase to 50mg
2-3 times daily; after 14 days, may increase to 150mg 3 times
daily if needed
-
Child:
Drug
Interactions:
-
Allopurinol:
increased risk of hypersensitivity reactions including Stevens-Johnson
syndrome, skin eruptions, fever, and arthralgias
-
NSAIDS:
inhibits the antihypertensive response to ACE inhibition
-
Lithium:
increased risk of lithium toxicity
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The information contained here is an
abbreviated summary. For more detailed and complete information, consult the
manufacturer's product information sheets or standard textbooks
Source: Operational Medicine 2001, Health
Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau
of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington,
D.C., 20372-5300
This information is provided by The Brookside Associates. The Brookside
Associates, LLC. is a private organization, not affiliated with any governmental
agency. The opinions presented here are those of the author and do not
necessarily represent the opinions of the Brookside Associates or the Department
of Defense. The presence of any advertising on these pages does not constitute
an endorsement of that product or service by either the US Department of Defense
or the Brookside Associates. All material presented here is unclassified.
C. 2009, 2014, All Rights Reserved
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