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PTT (Partial Thromboplastin Time)
PTT detects nearly all abnormalities in clotting, due to deficiencies in clotting factors or circulating anticoagulants.

It is frequently used to monitor heparin therapy.

A modification of the test, "Activated PTT," or APTT, is basically the same as PTT, but is slightly more sensitive.

Prolonged PTT is associated with:

  • Liver disease
  • Vitamin K deficiency
  • Anticoagulant (Coumarin, Coumadin, Heparin) therapy
  • DIC
  • Hemophilia

Therapeutic Range (Heparin Therapy)

  • 2-2.5 times the normal

Normal Values*

PTT 30-45 seconds 
APTT 16-25 seconds
Therapeutic Range on oral anticoagulants 2-2.5 times normal

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

Military Obstetrics & Gynecology
© 2003, 2004, 2005, 2006 Medical Education Division, Brookside Associates, Ltd.
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This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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