Ampicillin with Sulbactam (Unisyn)

Category:

  • Antibiotic

Description:

  • Penicillin with beta-lactamase inhibitor

  • 500mg of sulbactam per 1 gram of ampicillin

Indications:

  • Mild to moderate infections (i.e.; skin, intra-abdominal and gynecological infections)

  • susceptible strains of S. aureus, Klebsiella species, E. coli, H. influenzae, P. mirabilis, Bacteroides fragilis, Enterobacter species, Acinetobacter calcoaceticus

Contraindications:

  • None

Precautions:

  • Pregnancy category B

  • Use with caution in patients with PCN or cephalosporin allergy (5-10% chance of cross-reactivity)

  • Dosage modifications are generally only required in patients with severe renal impairment

Adverse Reactions (Side Effects):

  • Hypersensitivity (rash not representing a true allergy)

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis

Dosage:

  • Administered IV or IM (powder for injection)

  • Adult:

    • 1.5-3 grams every 6 hours (not to exceed 4 grams per day of sulbactam component)

  • Child (>1 year old or < 40kg):

    • 300mg/kg/day in divided doses every 6 hours

  • Child (> 40kg):

    • adult dosing guidelines

 

 

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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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