Neomycin

Category:

  • Antibiotic

Description:

  • Aminoglycoside antibiotic

Indications:

  • Suppression of bowel intestinal bacteria

  • Hepatic coma

Contraindications:

  • Presence of intestinal obstruction

  • Generally not indicated for long-term therapy due to nephrotoxocity and ototoxicity

Precautions:

  • Pregnancy category D

  • May cause nephrotoxicity, therefore closely monitor renal function, especially in elderly patients.

  • May cause ototoxicity, therefore monitor hearing

  • Aminoglycosides have neuromuscular blockade activity with a curare-like effect.  Monitor patient’s neuromuscular function, especially in patients with myasthenia gravis, parkinsonism or infant botulism.

  • Used in combination for bowel surgery preparation (used with minimal diet, bisacodyl, magnesium sulfate, enema, and supplemental IV fluids)

Adverse Reactions (Side Effects):

  • Gastrointestinal: vomiting, nausea, anorexia

  • “Malabsorption syndrome” characterized by increase in fetal fat, decrease in serum carotene and fall in xylose absorption

  • Increases fecal bile acid excretion and reduces intestinal lactase activity

Dosage:

  • Administered orally

  • Hepatic coma:

    • Adults: 4-12 grams per day in divided doses

    • Children: 50-100mg/kg/day in divided doses for a period of 5-10 days

  • Bowel preparation:

    • 1 gram (in combination with 1 gram erythromycin) for three doses at time periods of time of actual surgery minus 19 hours (T-19), minus 18 hours (T-18) and minus 9 hours (T-9)

 

 

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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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