Lisinopril
(Prinivil, Zestril)
Category:
Description:
Indications:
Precautions:
-
Pregnancy
category C (1st trimester), D (2nd and 3rd trimester); ACE inhibitors can cause fetal and neonatal morbidity and
death when administered to pregnant women
-
Impaired
renal function, dialysis patients, hypovolemia
-
Diuretic
therapy, collagen-vascular diseases, elderly, bilateral renal artery
stenosis
Adverse
Reactions (Side Effects):
-
CNS:
anxiety, dizziness, fatigue, headache, insomnia, paresthesia
-
CV:
angina, hypotension, palpitations, postural hypotension, syncope
(especially with 1st dose)
-
GI:
abdominal pain, constipation, melena, nausea, vomiting
-
GU:
acute renal failure, decreased libido, impotence, increased BUN,
creatinine
-
HEME:
agranulocytosis, neutropenia
-
METAB:
hyperkalemia, hyponatremia
-
MS:
arthralgia, arthritis, myalgia
-
RESP:
asthma, bronchitis, cough, dyspnea, sinusitis
-
SKIN:
angioedema, flushing, rash, sweating
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Dosage:
Administered
orally
-
Adult:
-
Hypertension: PO 10mg daily; usual dose 20-40mg daily
-
CHF: PO 5mg daily; usual range 5-20mg daily
-
Acute
MI: PO in hemodynamically stable patients within 24 hours of
acute MI, 5mg followed by 5mg after 24 hours, 10mg after 48 hours,
then 10mg daily; continue 6 weeks (or longer if concurrent
hypertension or CHF)
-
Renal
impairment: PO initial dose 5mg daily (serum creatinine >
or = to 3 mg/dl); initial dose 2.5mg daily (dialysis patients)
Drug
interactions:
-
Allopurinol:
predisposition to hypersensitivity reactions to ACE inhibitors
-
Aspirin,
NSAIDs: inhibition of the antihypertensive response to ACE inhibitors
-
Prazosin,
terazosin, doxazosin: exaggerated first-dose hypotensive response to a-blockers
|
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Distribution is unlimited. The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.
Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.
Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300 |
Operational Medicine
Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
January 1, 2001 |
United States Special Operations
Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323 |
*This web version is provided by The Brookside Associates, LLC. It contains
original contents from the official US Navy NAVMED P-5139, but has been
reformatted for web access and includes advertising and links that were not
present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the
Department of the Navy or the Department of Defense. The presence of any
advertising on these pages does not constitute an endorsement of that product or
service by either the US Department of Defense or the Brookside Associates. The
Brookside Associates is a private organization, not affiliated with the United
States Department of Defense.
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