Cephradine (Velosef)

Category:

  • Antibiotic

Description:

  • Cephalosporin, First Generation

Indications:

  • Respiratory tract infections (S. pneumoniae, group A beta-hemolytic streptococci)

  • Otitis media (S. pneumoniae, H. influenzae, staphylococci, group A beta-hemolytic streptococci)

  • Urinary tract infections (E. coli, Klebsiella species, P. mirabilis)

  • Skin, bone, and joint infections (staphylococci, A beta-hemolytic streptococci)

Contraindications:

  • Cross sensitivity with penicillin allergies

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

Adverse Reactions (Side Effects):

  • Hypersensitivity reactions

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  

Dosage:

  • Administered orally (capsules and oral suspension) and by IM or IV injection

  • Adults:

    • Skin, Resp Tract infections: 250mg every 6 hours or 500mg every 12 hours

    • Lobar pneumonia: 500mg every 6 hours or 1 gram every 12 hours

    • Uncomplicated UTI: 500mg every 12 hours

    • Serious infections and prostatitis: 500mg every 6 hours or 1 gram every 12 hours

  • Children > 9 months old:

    • 25-50mg/kg/day in divided doses every 6 or 12 hours

    • Otitis media form H. influenzae: 75-100mg/kg/day every 6 or 12 hours (not to exceed 4 grams a day)

  • Parenteral:

    • Adults: 2-4 grams in equally divided does 4 times a day

    • Bone infections: 1 gram IV four times a day

    • Cesarean section: 1 gram IV immediately after umbilical cord is clamped, give 2d and 3rd doses as 1 gram IM or IV at 6-12 hours after first dose

  • Perioperative prophylaxis:

    • Pre-op: 1 gram IV or IM, 30 to 90 minutes pre-surgery

    • Intra- and Post-operative (>2 hours): 1 gram IV or IM every 4 to 6 hours for 1 or 2 dose

 

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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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