Acetylcysteine (Mucomyst, Mucosil)

Category:

  • Miscellaneous

Description:

  • Mucolytic, acetaminophen antidote

Indications:

  • Antidote for acetaminophen overdose

  • Mucolytic

  • Adjunct therapy for abnormal, viscid, or inspissated mucus secretions in chronic broncho-pulmonary disease

Contraindications:

  • Increased intracranial pressure

  • Status asthmaticus

Precautions:

  • Pregnancy category B

  • Hypothyroidism; Addison’s disease, CNS depression, brain tumor, asthma, COPD

  • Hepatic disease, alcoholism, seizure disorders, renal disease, psychosis

  • AVOID use with iron, copper, rubber

  • Disagreeable odor may be noted

  • Discoloration of solution is of no significance

Adverse Reactions (Side Effects):

  • CNS: chills, dizziness, drowsiness, fever, headache

  • EENT: rhinorrhea

  • GI: anorexia, nausea, stomatitis, vomiting

  • RESP: bronchospasm, chest tightness

  • SKIN: clamminess, fever, rash, urticaria

Dosage:

Administered via nebulization (inhalation) or orally

Adult and Child:

  • Mucolytic: 

    • Instill 1-2 ml (10%-20% solution) every 1-4 hours as needed

    • nebulize 3-5 ml (20% solution) or 6-10 ml (10% solution) three times daily

  • Acetaminophen toxicity: 

    • PO 140 mg/kg, then 70 mg/kg every 4 hours for 17 doses to total 1330 mg/kg; (dilute 20% solution to concentration of 5%; dilutions should be freshly prepared and utilized within 1 hour)

 

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Approved for public release; Distribution is unlimited.

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks.

Source: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300.

Bureau of Medicine and Surgery
Department of the Navy
2300 E Street NW
Washington, D.C
20372-5300

Operational Medicine
 Health Care in Military Settings
CAPT Michael John Hughey, MC, USNR
NAVMED P-5139
  January 1, 2001

United States Special Operations Command
7701 Tampa Point Blvd.
MacDill AFB, Florida
33621-5323

*This web version is provided by The Brookside Associates, LLC.  It contains original contents from the official US Navy NAVMED P-5139, but has been reformatted for web access and includes advertising and links that were not present in the original version. The medical information presented was reviewed and felt to be accurate in 2001. Medical knowledge and practice methods may have changed since that time. Some links may no longer be active. This web version has not been approved by the Department of the Navy or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. The Brookside Associates is a private organization, not affiliated with the United States Department of Defense.

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