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Magnesium Sulfate

Category:

  • Nervous System

Description:

  • Antiarrhythmic, uterine relaxant, electrolyte supplement

Indications:

  • Hypomagnesemia

  • Eclampsia prophylaxis

  • Preterm labor (non FDA approved)

Contraindications:

  • Renal failure, hypermagnesemia; appendicitis, bowel obstruction/perforation

  • Patients with heart block or myocardial damage

Precautions:

  • Pregnancy category B

  • Diarrhea, digitalized patients, impaired renal function

Adverse Reactions (Side Effects):

  • CNS: coma, depressed deep tendon reflexes, lethargy, weakness

  • CV: decreased BP, heart block, increased pulse

  • METAB: hypermagnesemia

  • RESP: respiratory distress

 

 

 

Dosage:

Administered parenterally

  • Adult:  

    • IM 4-5g of 50% solution every 4 hours as needed

    • IV 4g of a 10%-20% solution initially then 4-5g in 250ml of D5W or NS at a rate not exceeding 3 ml/min by infusion (pre-eclampsia)

    • IM/IV 1g every 6 hours for 4 doses; for severe deficiency, 8-12g daily in divided doses (hypomagnesemia); PO 10-15g in a glass of water (laxative)

  • Child: 

    • Neonate IV 25-50 mg/kg/dose every 8-12 hours for 2-3 doses

    • child 

      • IM/IV 25-50 mg/kg/dose every 4-6 hours for 3-4 doses, max single dose 2000mg (hypomagnesemia); 

      • PO 5-10g in a glass of water (laxative)

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks. Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
© 2003, 2004, 2005, 2008 Medical Education Division, Brookside Associates, Ltd.
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