OB-GYN 101
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Hydralazine (Apresoline)

Category:

  • Miscellaneous

Description:

  • Antihypertensive; (preferentially dilates arterioles)

Indications:

  • Hypertension

Contraindications:

  • Coronary artery disease

  • Valvular rheumatic heart disease

Precautions:

  • Pregnancy category C

  • Advanced renal disease, children, pulmonary hypertension

Adverse Reactions (Side Effects):

  • CNS: anxiety, dizziness, headache, peripheral neuritis, psychotic reactions, tremor

  • CV: angina, edema, flushing, hypotension, palpitations, reflex tachycardia

  • EENT: nasal congestion

  • GI: anorexia, constipation, diarrhea, hepatitis, paralytic ileus, nausea, vomiting

  • GU: urination difficulty

  • HEME: agranulocytosis, anemia, eosinophilia, leukopenia

  • SKIN: pruritis, rash, urticaria

  • MISC: lupus-like syndrome, arthralgia, muscle cramps

 

 

 

Dosage:

Administered orally (tablet), intramuscularly, and intravenously

  • Adult:   

    • PO 10mg 4 times daily, increase by 10-25 mg/dose every 2-5 days as needed to max of 300 mg/day

    • IM/IV 10-20mg every 4-6 hours, may increase to 40 mg/dose

  • Child:   

    • PO 0.75-1 mg/kg/day divided 2-4 times daily, increase over 3-4 weeks to 7.5 mg/kg/day divided 2-4 times daily if necessary, do not exceed 200 mg/day

    • IM/IV 0.1-0.2 mg/kg/dose every 4-6 hours, do not exceed 20 mg/dose

Special Considerations:

  • May cause black stools

  •  Take with meals

  •  Lupus-like syndrome more common in “slow acetylators” and folling higher doses for prolonged periods

  •  Patient to notify clinician of any unexplained prolonged general tiredness, or fever, muscle or joint aching, or chest pain

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks. Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
© 2003, 2004, 2005, 2008 Medical Education Division, Brookside Associates, Ltd.
All rights reserved

 

 

 

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