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Ethynodiol Diacetate and Ethinyl Estradiol (Demulin 1/35)

Category:

  • Hormone

Description:

  • Monophasic oral contraceptive

  • Demulin 1/35: ethynodiol diacetate 1mg, ethinyl estradiol 35mcg

Indications:

  • Contraception

Contraindications:

  • Pregnancy

  • Undiagnosed abnormal vaginal bleeding

  • Known or suspected benign or malignant liver tumors while on oral contraceptive use

  • Breast carcinoma or estrogen-dependent neoplasia

  • Current or history of thromboembolic disorders, cerebral vascular or cardiovascular disease.

Precautions:

  • Pregnancy category X

  • Take as directed at intervals not exceeding 24 hours.  Efficiency is dependent upon strict compliance.

  • Breakthrough bleeding (“spotting”) may occur during initiation of therapy.

  • OCPs are 99.9% effective after the 1st month, if taken according to the prescribed schedule. 

  • During the first month, effectiveness depends on how many OCPs have been taken, but overall are about 95% effective, comparable to condoms or a diaphragm.

  • Instructions for missed doses:

    • One missed dose: Take as soon as possible or two tablets the next day and continue

    • Two missed doses: Take two tablets daily for two days, then continue normal schedule

    • Three missed doses: Discontinue therapy and begin new packet 7 days following last dose

  • May cause mental depression, fluid retention and depressed folate levels

  • Twenty-eight day packs contain seven days of inert ingredients to maintain regimen

Adverse Reactions (Side Effects):

  • Abdominal cramping, anorexia, nausea, vomiting

  • Acne (Usually makes it better)

  • Breast tenderness

  • Edema, weight gain

  • Unusual tiredness or weakness

  • Cardiovascular disorders (hypertension)

  • Thromboembolic disorders

 

 

 

Dosage:

  • Administered orally

  • One tablet daily for 21 or 28 days beginning on the:

    • Fifth day of the cycle, or

    • First Sunday after the beginning of flow

For more information on Oral Contraceptive Pills, read:

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks. Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
© 2003, 2004, 2005, 2008 Medical Education Division, Brookside Associates, Ltd.
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