OB-GYN 101
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Diphenoxylate/Atropine (Lomotil, Lonox, Lomanate, Logen)

Category:

  • Gastrointestinal

Description:

  • Antidiarrheal: DEA Schedule V

Indications:

  • Diarrhea

  • Reduction of ileostomy discharge

Contraindications:

  • Obstructive jaundice

  • Diarrhea associated with pseudomembranous enterocolitis or entertoxin-producing bacteria

Precautions:

  • Pregnancy category C; excreted in breast milk

  • Acute ulcerative colitis (may induce toxic megacolon)

  • Severe hepatorenal disease

Adverse Reactions (Side Effects):

  • Central Nervous System: fatigue, dizziness, drowsiness

  • Gastrointestinal: abdominal pain or distention, constipation, ileus, nausea, vomiting

  • Dry Mouth

  • Rash

 

 

 

Dosage:

Administered orally (tablets, solution)

  • Tablet: 2.5mg diphenoxylate/0.025mg atropine 

  • Solution: 2.5mg diphenoxylate/0.025mg atropine per 5ml

  • Adult: 5mg (2 tablets) four times daily, taper dose as tolerated

  • Child: 0.3-0.4mg/kg daily in 4 divided doses

 

The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks. Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

OB-GYN 101: Introductory Obstetrics & Gynecology
© 2003, 2004, 2005, 2008 Medical Education Division, Brookside Associates, Ltd.
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