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Oxacillin (Bactocill)

Category:

  • Antibiotic

Description:

  • Penicillinase-Resistant Penicillin

Indications:

  • Mild to moderate infections caused by penicillinase-producing staphylococci

  • Upper Respiratory Tract Infections

  • Localized soft tissue/skin infections

  • Lower Respiratory Tract Infections

  • Disseminated infections

Contraindications:

  • None

Precautions:

  • Pregnancy category B

  • Use with caution in patients with penicillin or cephalosporin allergy (5-10% chance of cross-reactivity)

  • Counsel patient to finish all medication to prevent development of resistance

  • Inform patient to take at even intervals, preferably around the clock

  • Take on an empty stomach, 1 hour before or 2 hours after meals.  Food inhibits absorption

  • Parenteral dosage form should not be run in same IV line as other medications

  • Inject intravenous injection slowly over a period of 10 minutes

Adverse Reactions (Side Effects):

  • Hypersensitivity

  • Gastrointestinal: nausea, vomiting, diarrhea

  • Vaginitis  

Dosage:

Administered orally (capsules and oral suspension) and injectable

  • Oral

    • Adult and children (>40kg):

      • 500mg q4-6h (may increase to 1 gram q4-6h for severe infections)

    • Infants and children (<40kg):

      • 50mg/kg/day in divided doses every 6 hours

    • Neonates (>2kg) (age < 7 days):

      • 75mg/kg/day divided every 8 hours

    • Neonates (>2kg) (age > 7 days):

      • 150mg/kg/day every 6 hours

    • Neonates (<2kg):

      • 50mg/kg/day divided every 12 hours

  • Injectable

    • Adult and children (>40kg):

      • 250-500mg IM or IV q4-6h (up to 1 gram q-46h for severe infections)

    • Infants and children (<40kg):

      • 50mg/kg/day IM or IV in equally divided doses every 6 hours

      • severe infections: 100mg/kg/day IM or IV in equally divided doses every 4-6 hours

    • Premature/Neonates:

      • 25mg/kg/day IM or IV in divided doses

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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